Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome
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منابع مشابه
Epigenetic Transgenerational Actions of Vinclozolin on Promoter Regions of the Sperm Epigenome
Previous observations have demonstrated that embryonic exposure to the endocrine disruptor vinclozolin during gonadal sex determination promotes transgenerational adult onset disease such as male infertility, kidney disease, prostate disease, immune abnormalities and tumor development. The current study investigates genome-wide promoter DNA methylation alterations in the sperm of F3 generation ...
متن کاملEpigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers.
The endocrine disruptor vinclozolin has previously been shown to promote epigenetic transgenerational inheritance of adult onset disease in the rat. The current study was designed to investigate the transgenerational actions of vinclozolin on the mouse. Transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 ...
متن کاملAncestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
Exposure to the agricultural fungicide vinclozolin during gestation promotes a higher incidence of various diseases in the subsequent unexposed F3 and F4 generations. This phenomenon is termed epigenetic transgenerational inheritance and has been shown to in part involve alterations in DNA methylation, but the role of other epigenetic mechanisms remains unknown. The current study investigated t...
متن کاملErratum: Ancestral vinclozolin exposure alters the epigenetic transgenerational inheritance of sperm small noncoding RNAs
[This corrects the article DOI: 10.1093/eep/dvw001.].
متن کاملEndocrine disruptor vinclozolin induced epigenetic transgenerational adult-onset disease.
The fetal basis of adult disease is poorly understood on a molecular level and cannot be solely attributed to genetic mutations or a single etiology. Embryonic exposure to environmental compounds has been shown to promote various disease states or lesions in the first generation (F1). The current study used the endocrine disruptor vinclozolin (antiandrogenic compound) in a transient embryonic e...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0013100